A Short Route to Chiral Synthons: Preparation of Ketoeicosanoids with Hydropyrane Fragments

A Short Route to Chiral Synthons: Preparation of Ketoeicosanoids with Hydropyrane Fragments

To prepare ketoeicosanoids with hydropyrane fragments, new synthons were obtained from the BF 3·OEt 2 catalysed reaction of tri- O-acetyl- d-glucal with methyl 5-trimethylsilyloxyhex-5-enoate, methyl 10-trimethylsilyloxyundec-10-enoate and the bis(trimethylsilyl)ether of o-hydroxyacetophenone.

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Veröffentlicht in:Mendeleev communications 1993, Vol.3 (1), p.18-20
Hauptverfasser: Tolstikov, Aleksander G., Savateeva, Elena E., Khakhalina, Nina V., Spirikhin, Leonid V., Sultanmuratova, Vilina R., Tolstikov, Genrikh A.
Format: Artikel
Sprache:eng
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Zusammenfassung:To prepare ketoeicosanoids with hydropyrane fragments, new synthons were obtained from the BF 3·OEt 2 catalysed reaction of tri- O-acetyl- d-glucal with methyl 5-trimethylsilyloxyhex-5-enoate, methyl 10-trimethylsilyloxyundec-10-enoate and the bis(trimethylsilyl)ether of o-hydroxyacetophenone.
ISSN:0959-9436
DOI:10.1070/MC1993v003n01ABEH000202