Ophthalmic drops causing coma in an infant

A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects f...

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Veröffentlicht in:	The Journal of pediatrics 2001-03, Vol.138 (3), p.441-443
Hauptverfasser:	Berlin, Randall J., Lee, Uyen T., Samples, John R., Rich, Larry F., Tang-Liu, Diane D-S., Sing, Kimberly A., Steiner, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - poisoning Biological and medical sciences Brimonidine Tartrate Coma - complications Coma - etiology Coma - prevention & control Drug toxicity and drugs side effects treatment Eye Abnormalities - complications Humans Infant, Newborn Male Medical sciences Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - poisoning Pharmacology. Drug treatments Practice Guidelines as Topic Quinoxalines - administration & dosage Quinoxalines - poisoning Syndrome Toxicity: cardiovascular system Toxicity: nervous system and muscle
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Beschreibung
Zusammenfassung:	A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects from the systemic absorption of topically applied ophthalmic agents in children. (J Pediatr 2001;138:441-3)
ISSN:	0022-3476 1097-6833
DOI:	10.1067/mpd.2001.111319