Au nanorods can be used for long-term cell imaging?

The photostability of Au nanorods in human hepatocellular carcinoma cells under two-photon excitation was investigated to evaluate their potential in cell imaging. The photoluminescence images of the intracellular Au nanorods under the two-photon excitation of an 800 nm femtosecond laser were photob...

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Veröffentlicht in:Applied physics letters 2011-05, Vol.98 (21), p.213704-213704-3
Hauptverfasser: Wu, Xi, Yang, Fei, Ming, Tian, Xiong, Rongling, Wang, Peinan, Chen, Jiyao
Format: Artikel
Sprache:eng
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Zusammenfassung:The photostability of Au nanorods in human hepatocellular carcinoma cells under two-photon excitation was investigated to evaluate their potential in cell imaging. The photoluminescence images of the intracellular Au nanorods under the two-photon excitation of an 800 nm femtosecond laser were photobleached rapidly, which is due to the melting of Au nanorods. The images lost their brightness for more than 50% after 15 micrograph scans for the nanorod incubation concentrations of 10, 20, and 40 pM. The confocal reflectance image can prevent the image photobleaching and thus is suitable for long-term cell imaging with Au nanorods.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.3593961