Mucosal wrinkling in animal antra induced by volumetric growth

Surface wrinkling of animal mucosas is crucial for the biological functions of some tissues, and the change in their surface patterns is a phenotypic characteristic of certain diseases. Here we develop a biomechanical model to study the relationship between morphogenesis and volumetric growth, eithe...

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Veröffentlicht in:Applied physics letters 2011-04, Vol.98 (15), p.153701-153701-3
Hauptverfasser: Li, Bo, Cao, Yan-Ping, Feng, Xi-Qiao, Yu, Shou-Wen
Format: Artikel
Sprache:eng
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Zusammenfassung:Surface wrinkling of animal mucosas is crucial for the biological functions of some tissues, and the change in their surface patterns is a phenotypic characteristic of certain diseases. Here we develop a biomechanical model to study the relationship between morphogenesis and volumetric growth, either physiological or pathological, of mucosas. Theoretical analysis and numerical simulations are performed to unravel the critical characteristics of mucosal wrinkling in a spherical antrum. It is shown that the thicknesses and elastic moduli of mucosal and submucosal layers dictate the surface buckling morphology. The results hold clinical relevance for such diseases as inflammation and gastritis.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.3579142