Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis

A cluster-randomized trial in 20 Ugandan health centers compared a multicomponent strategy (on-site molecular testing for TB, restructuring of clinic workflows, and feedback of quality metrics) with routine care (on-site sputum-smear microscopy and referral-based molecular testing). The intervention...

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Veröffentlicht in:	The New England journal of medicine 2021-12, Vol.385 (26), p.2441-2450
Hauptverfasser:	Cattamanchi, Adithya, Reza, Tania F, Nalugwa, Talemwa, Adams, Katherine, Nantale, Mariam, Oyuku, Denis, Nabwire, Sarah, Babirye, Diana, Turyahabwe, Stavia, Tucker, Austin, Sohn, Hojoon, Ferguson, Olivia, Thompson, Ryan, Shete, Priya B, Handley, Margaret A, Ackerman, Sara, Joloba, Moses, Moore, David A.J, Davis, J. Lucian, Dowdy, David W, Fielding, Katherine, Katamba, Achilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Community Health Centers - organization & administration Diagnosis Female General & Internal Medicine Global Health Health facilities HIV HIV Infections - complications HIV Infections - diagnosis Human immunodeficiency virus Humans Infectious Disease Intervention Life Sciences & Biomedicine Male Medical diagnosis Medical laboratories Medicine, General & Internal Microscopy Middle Aged Models, Statistical Molecular biology Molecular Diagnostic Techniques Nucleic Acid Amplification Techniques Onsite Patients Point-of-Care Testing Science & Technology Sputum Statistical analysis Time-to-Treatment Tuberculosis Tuberculosis - complications Tuberculosis - diagnosis Tuberculosis - drug therapy Uganda
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Beschreibung
Zusammenfassung:	A cluster-randomized trial in 20 Ugandan health centers compared a multicomponent strategy (on-site molecular testing for TB, restructuring of clinic workflows, and feedback of quality metrics) with routine care (on-site sputum-smear microscopy and referral-based molecular testing). The intervention led to greater numbers of patients being tested for, receiving a diagnosis of, and being treated for confirmed TB.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2105470