A Monoclonal Antibody for Malaria Prevention

Malaria remains a cause of substantial global morbidity and mortality. In this report, an engineered monoclonal antibody showed protection against malaria infection in a controlled human infection model.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-08, Vol.385 (9), p.803-814
Hauptverfasser:	Gaudinski, Martin R, Berkowitz, Nina M, Idris, Azza H, Coates, Emily E, Holman, LaSonji A, Mendoza, Floreliz, Gordon, Ingelise J, Plummer, Sarah H, Trofymenko, Olga, Hu, Zonghui, Campos Chagas, Andrezza, O’Connell, Sarah, Basappa, Manjula, Douek, Naomi, Narpala, Sandeep R, Barry, Christopher R, Widge, Alicia T, Hicks, Renunda, Awan, Seemal F, Wu, Richard L, Hickman, Somia, Wycuff, Diane, Stein, Judy A, Case, Christopher, Evans, Brian P, Carlton, Kevin, Gall, Jason G, Vazquez, Sandra, Flach, Britta, Chen, Grace L, Francica, Joseph R, Flynn, Barbara J, Kisalu, Neville K, Capparelli, Edmund V, McDermott, Adrian, Mascola, John R, Ledgerwood, Julie E, Seder, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergies Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - therapeutic use Antibodies, Protozoan - blood Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacokinetics Antimalarials - therapeutic use Body weight Clinical trials Coronaviruses COVID-19 Disease Dose-Response Relationship, Drug Global Health Health care Healthy Volunteers Humans Infections Infectious Disease Infectious diseases Infusions, Intravenous - adverse effects Injections Injections, Subcutaneous - adverse effects Malaria Malaria, Falciparum - prevention & control Middle Aged Monoclonal antibodies Morbidity Mosquitoes Parasitemia Parasitic Infections Pharmacokinetics Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - isolation & purification Polymerase chain reaction Proteins Safety Sporozoites Vaccination Vaccines
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Beschreibung
Zusammenfassung:	Malaria remains a cause of substantial global morbidity and mortality. In this report, an engineered monoclonal antibody showed protection against malaria infection in a controlled human infection model.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2034031