$CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus$

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen recepto...

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Veröffentlicht in:	The New England journal of medicine 2021-08, Vol.385 (6), p.567-569
Hauptverfasser:	Mougiakakos, Dimitrios, Krönke, Gerhard, Völkl, Simon, Kretschmann, Sascha, Aigner, Michael, Kharboutli, Soraya, Böltz, Sebastian, Manger, Bernhard, Mackensen, Andreas, Schett, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Antigens Antigens, CD19 Arthritis Autoimmune Disease Autoimmune diseases CD19 antigen Chimeric antigen receptors Creatinine Disease Endocarditis Estrogens Female General & Internal Medicine Genetics Humans Immunity Immunology Immunosuppression Immunotherapy, Adoptive Life Sciences & Biomedicine Lupus Lupus Erythematosus, Systemic - therapy Lupus nephritis Lymphocytes Lymphocytes T Medicine, General & Internal Nephritis Nephrotic syndrome Pathogenesis Pericarditis Pleurisy Receptors, Chimeric Antigen - metabolism Remission (Medicine) Remission Induction - methods Rheumatology Rheumatology General Science & Technology Systemic lupus erythematosus Young Adult
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