CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen recepto...

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Veröffentlicht in:The New England journal of medicine 2021-08, Vol.385 (6), p.567-569
Hauptverfasser: Mougiakakos, Dimitrios, Krönke, Gerhard, Völkl, Simon, Kretschmann, Sascha, Aigner, Michael, Kharboutli, Soraya, Böltz, Sebastian, Manger, Bernhard, Mackensen, Andreas, Schett, Georg
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Sprache:eng
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Zusammenfassung:A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen receptor T cells.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2107725