CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus
A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen recepto...
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Veröffentlicht in: | The New England journal of medicine 2021-08, Vol.385 (6), p.567-569 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen receptor T cells. |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJMc2107725 |