CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen recepto...

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Veröffentlicht in:The New England journal of medicine 2021-08, Vol.385 (6), p.567-569
Hauptverfasser: Mougiakakos, Dimitrios, Krönke, Gerhard, Völkl, Simon, Kretschmann, Sascha, Aigner, Michael, Kharboutli, Soraya, Böltz, Sebastian, Manger, Bernhard, Mackensen, Andreas, Schett, Georg
Format: Artikel
Sprache:eng
Schlagworte:
Allergy
Antigens
Antigens, CD19
Arthritis
Autoimmune Disease
Autoimmune diseases
CD19 antigen
Chimeric antigen receptors
Creatinine
Disease
Endocarditis
Estrogens
Female
General & Internal Medicine
Genetics
Humans
Immunity
Immunology
Immunosuppression
Immunotherapy, Adoptive
Life Sciences & Biomedicine
Lupus
Lupus Erythematosus, Systemic - therapy
Lupus nephritis
Lymphocytes
Lymphocytes T
Medicine, General & Internal
Nephritis
Nephrotic syndrome
Pathogenesis
Pericarditis
Pleurisy
Receptors, Chimeric Antigen - metabolism
Remission (Medicine)
Remission Induction - methods
Rheumatology
Rheumatology General
Science & Technology
Systemic lupus erythematosus
Young Adult
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Beschreibung
Zusammenfassung:A 20-year-old woman with refractory SLE with active lupus nephritis (WHO class IIIA), nephrotic syndrome, pericarditis, pleurisy, rash, arthritis, and a history of Libman–Sacks endocarditis refractory to conventional immunosuppression had a complete response to CD19-specific chimeric antigen receptor T cells.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2107725