Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters

Abstract 2,6-Disubstituted 5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from α-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cyclization.

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Veröffentlicht in:Synthesis (Stuttgart) 2007-11, Vol.2007 (21), p.3301-3308
Hauptverfasser: Li, Lian-Sheng, Zhou, Yuefen, Zhao, Jingjing, Dragovich, Peter S., Stankovic, Nebojsa, Bertolini, Thomas M., Murphy, Douglas E., Sun, Zhongxiang, Tran, Chinh V., Ayida, Benjamin K., Ruebsam, Frank, Webber, Stephen E.
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Sprache:eng
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Zusammenfassung:Abstract 2,6-Disubstituted 5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from α-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cyclization.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-990823