Laboratory-Scale Synthesis of Nitriles by Catalysed Dehydration of Amides and Oximes under Flash Vacuum Pyrolysis (FVP) Conditions

Laboratory-Scale Synthesis of Nitriles by Catalysed Dehydration of Amides and Oximes under Flash Vacuum Pyrolysis (FVP) Conditions

Abstract Dehydration of amides and oximes can be catalysed by 3 Å molecular sieves or by tungsten trioxide under flash vacuum pyrolysis (FVP) conditions. This provides a convenient synthesis of aliphatic, aromatic, and heterocyclic nitriles, generally in excellent yields under mild, neutral, and sho...

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Veröffentlicht in:Synthesis (Stuttgart) 2007-10, Vol.2007 (20), p.3179-3184
Hauptverfasser: Campbell, Jacqueline A., McDougald, Graham, McNab, Hamish, Rees, Lovat V., Tyas, Richard G.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Dehydration of amides and oximes can be catalysed by 3 Å molecular sieves or by tungsten trioxide under flash vacuum pyrolysis (FVP) conditions. This provides a convenient synthesis of aliphatic, aromatic, and heterocyclic nitriles, generally in excellent yields under mild, neutral, and short contact time conditions.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-990782