Synthesis of Novel 2,6-Diazaspiro[3.3]heptanes

Abstract A practical route to 2,6-diazaspiro[3.3]heptanes is described by way of reductive amination of a readily available aldehyde with primary amines or anilines. Cyclisation proceeds in high yield and the methods reported are amenable to either library or large-scale synthesis.

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Veröffentlicht in:	Synlett 2007-10, Vol.2007 (16), p.2584-2586
Hauptverfasser:	Hamza, Daniel, Stocks, Michael J., Décor, Anne, Pairaudeau, Garry, Stonehouse, Jeffrey P.
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Sprache:	eng
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description	Abstract A practical route to 2,6-diazaspiro[3.3]heptanes is described by way of reductive amination of a readily available aldehyde with primary amines or anilines. Cyclisation proceeds in high yield and the methods reported are amenable to either library or large-scale synthesis.
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title	Synthesis of Novel 2,6-Diazaspiro[3.3]heptanes
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