Synthesis of Novel 2,6-Diazaspiro[3.3]heptanes

Synthesis of Novel 2,6-Diazaspiro[3.3]heptanes

Abstract A practical route to 2,6-diazaspiro[3.3]heptanes is described by way of reductive amination of a readily available aldehyde with primary amines or anilines. Cyclisation proceeds in high yield and the methods reported are amenable to either library or large-scale synthesis.

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Veröffentlicht in:Synlett 2007-10, Vol.2007 (16), p.2584-2586
Hauptverfasser: Hamza, Daniel, Stocks, Michael J., Décor, Anne, Pairaudeau, Garry, Stonehouse, Jeffrey P.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A practical route to 2,6-diazaspiro[3.3]heptanes is described by way of reductive amination of a readily available aldehyde with primary amines or anilines. Cyclisation proceeds in high yield and the methods reported are amenable to either library or large-scale synthesis.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-986650