A Facile Anchoring of the Bisphosphonate Moiety into Alcohols and Phenols through Copper Carbenoid Mediated O-H Insertion Reaction

A Facile Anchoring of the Bisphosphonate Moiety into Alcohols and Phenols through Copper Carbenoid Mediated O-H Insertion Reaction

Abstract A straightforward procedure ensuring the anchoring of bisphosphonate moiety into alcohols or phenols is described. The method uses a bisphosphonate-metal-carbenoid O-H insertion ­reaction for which copper(II) triflate was found to be an efficient catalyst.

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Veröffentlicht in:Synlett 2007-07, Vol.2007 (12), p.1863-1868
Hauptverfasser: Lecerclé, Delphine, Taran, Frédéric
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A straightforward procedure ensuring the anchoring of bisphosphonate moiety into alcohols or phenols is described. The method uses a bisphosphonate-metal-carbenoid O-H insertion ­reaction for which copper(II) triflate was found to be an efficient catalyst.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-984535