Chiral-Thiourea-Catalyzed Direct Mannich Reaction

Chiral-Thiourea-Catalyzed Direct Mannich Reaction

ABSTRACT In the presence of a chiral thiourea as a bifunctional organocatalyst, Mannich reaction of N-Boc-imine with prochiral 1,3-dicarbonyl compounds proceeded with excellent enantio- and dia­stereoselectivities.

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Veröffentlicht in:Synthesis (Stuttgart) 2007-08, Vol.2007 (16), p.2571-2575
Hauptverfasser: Yamaoka, Yousuke, Miyabe, Hideto, Yasui, Yoshizumi, Takemoto, Yoshiji
Format: Artikel
Sprache:eng
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special topic
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Zusammenfassung:ABSTRACT In the presence of a chiral thiourea as a bifunctional organocatalyst, Mannich reaction of N-Boc-imine with prochiral 1,3-dicarbonyl compounds proceeded with excellent enantio- and dia­stereoselectivities.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-983795