Towards the Synthesis of the Cornexistins

Towards the Synthesis of the Cornexistins

Abstract A concise synthetic route to the carbocyclic core of the cornexistins is reported. The route is highlighted by a Diels-Alder cycloaddition/oxidative cleavage strategy to generate the central highly functionalized nine-member ring. A silyl-tethered ring-closing metathesis strategy is utilize...

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Veröffentlicht in:Synthesis (Stuttgart) 2007-08, Vol.2007 (15), p.2388-2396
Hauptverfasser: Tung, James C., Chen, Wensheng, Noll, Bruce C., Taylor, Richard E., Fields, Stephen C., Dent III, William H., Green III, F. Richard
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A concise synthetic route to the carbocyclic core of the cornexistins is reported. The route is highlighted by a Diels-Alder cycloaddition/oxidative cleavage strategy to generate the central highly functionalized nine-member ring. A silyl-tethered ring-closing metathesis strategy is utilized to control trisubstituted alkene geometry.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-983769