Synthesis of Axially Chiral Cyclic Amine-Substituted 2-(Oxazolinyl)pyridine Ligands for Catalytic Asymmetric Fluorination of β-Keto Esters

Synthesis of Axially Chiral Cyclic Amine-Substituted 2-(Oxazolinyl)pyridine Ligands for Catalytic Asymmetric Fluorination of β-Keto Esters

ABSTRACT Novel optically active N,N,N-tridentate ligands, which possess both binaphthyl axial chirality and carbon-centered chirality, were prepared and successfully used in the catalytic asymmetric α-fluorination of β-keto esters giving ee values up to 94%.

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Veröffentlicht in:Synlett 2007-03, Vol.2007 (4), p.0551-0554
Hauptverfasser: Shibatomi, Kazutaka, Tsuzuki, Yuya, Nakata, Shin-ichi, Sumikawa, Yusuke, Iwasa, Seiji
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT Novel optically active N,N,N-tridentate ligands, which possess both binaphthyl axial chirality and carbon-centered chirality, were prepared and successfully used in the catalytic asymmetric α-fluorination of β-keto esters giving ee values up to 94%.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-970746