Buchwald-Hartwig Amination of β-Chloroacroleins by Lactams and Heteroarylamines
Abstract β-Chloroacroleins reacted readily with lactams and several heteroarylamines (aminopyridines, aminoquinoline and azoles) under standard Buchwald-Hartwig amination conditions. Both Pd(OAc) 2 /Binap or Pd(OAc) 2 /Xantphos were efficient catalytic systems in the presence of Cs 2 CO 3 as base.
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| Veröffentlicht in: | Synthesis (Stuttgart) 2007-05, Vol.2007 (10), p.1571-1575 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
β-Chloroacroleins reacted readily with lactams and several heteroarylamines (aminopyridines, aminoquinoline and azoles) under standard Buchwald-Hartwig amination conditions. Both Pd(OAc)
2
/Binap or Pd(OAc)
2
/Xantphos were efficient catalytic systems in the presence of Cs
2
CO
3
as base. |
|---|---|
| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2007-966034 |