novel isoflavonoid from Millettia puguensis
Abstract From the roots of MILLETTIA PUGUENSIS (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-m...
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| Veröffentlicht in: | Planta medica 2006-11, Vol.72 (14), p.1341-1343 |
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| container_title | Planta medica |
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| creator | Kapingu, M.C Mbwambo, Z.H Moshi, M.J Magadula, J.J Cos, P Berghe, D. vanden Maes, L Theunis, M Apers, S Pieters, L |
| description | Abstract
From the roots of MILLETTIA PUGUENSIS (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by
1
H-,
13
C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC
50
= 32 μM against LEISHMANIA INFANTUM), and a moderate cytotoxicity for compound 2 (IC
50
= 43 μM on MRC-5 cells). |
| doi_str_mv | 10.1055/s-2006-951689 |
| format | Article |
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From the roots of MILLETTIA PUGUENSIS (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by
1
H-,
13
C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC
50
= 32 μM against LEISHMANIA INFANTUM), and a moderate cytotoxicity for compound 2 (IC
50
= 43 μM on MRC-5 cells).</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-951689</identifier><identifier>PMID: 17054049</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; antiprotozoal agents ; Antiprotozoal Agents - administration & dosage ; Antiprotozoal Agents - pharmacology ; Antiprotozoal Agents - therapeutic use ; Biological and medical sciences ; chemical structure ; chemotaxonomy ; cytotoxicity ; Fabaceae ; General pharmacology ; human health ; Humans ; Inhibitory Concentration 50 ; isoflavones ; Isoflavones - administration & dosage ; Isoflavones - pharmacology ; Isoflavones - therapeutic use ; isoflavonoids ; Leishmania infantum ; Leishmania infantum - drug effects ; Leishmaniasis - drug therapy ; Letter ; maackiain ; Malaria, Falciparum - drug therapy ; Medical sciences ; medicinal plants ; Millettia ; Millettia puguensis ; Parasitic Sensitivity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; spectral analysis ; Trypanosoma - drug effects ; Trypanosoma brucei brucei ; Trypanosomiasis - drug therapy</subject><ispartof>Planta medica, 2006-11, Vol.72 (14), p.1341-1343</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-73185becf53cfa14755de3d9397cff2a644a33f2c59696bcc801989fe535e6533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-951689.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2006-951689$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18274997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17054049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kapingu, M.C</creatorcontrib><creatorcontrib>Mbwambo, Z.H</creatorcontrib><creatorcontrib>Moshi, M.J</creatorcontrib><creatorcontrib>Magadula, J.J</creatorcontrib><creatorcontrib>Cos, P</creatorcontrib><creatorcontrib>Berghe, D. vanden</creatorcontrib><creatorcontrib>Maes, L</creatorcontrib><creatorcontrib>Theunis, M</creatorcontrib><creatorcontrib>Apers, S</creatorcontrib><creatorcontrib>Pieters, L</creatorcontrib><title>novel isoflavonoid from Millettia puguensis</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
From the roots of MILLETTIA PUGUENSIS (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by
1
H-,
13
C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC
50
= 32 μM against LEISHMANIA INFANTUM), and a moderate cytotoxicity for compound 2 (IC
50
= 43 μM on MRC-5 cells).</description><subject>Animals</subject><subject>antiprotozoal agents</subject><subject>Antiprotozoal Agents - administration & dosage</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>chemotaxonomy</subject><subject>cytotoxicity</subject><subject>Fabaceae</subject><subject>General pharmacology</subject><subject>human health</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>isoflavones</subject><subject>Isoflavones - administration & dosage</subject><subject>Isoflavones - pharmacology</subject><subject>Isoflavones - therapeutic use</subject><subject>isoflavonoids</subject><subject>Leishmania infantum</subject><subject>Leishmania infantum - drug effects</subject><subject>Leishmaniasis - drug therapy</subject><subject>Letter</subject><subject>maackiain</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Millettia</subject><subject>Millettia puguensis</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>spectral analysis</subject><subject>Trypanosoma - drug effects</subject><subject>Trypanosoma brucei brucei</subject><subject>Trypanosomiasis - drug therapy</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1zztPwzAUhmELgWgpjKyQhQkMx7ckHlHFTSpigM6W69jFKIkrO6nEvydVKnViOsuj7-hF6JLAPQEhHhKmADmWguSlPEJTwpnEQCk5RlMARjFIziboLKUfAMIlwCmakAIEBy6n6LYNW1tnPgVX621og68yF0OTvfu6tl3ndbbp171tk0_n6MTpOtmL_Z2h5fPT1_wVLz5e3uaPC2xYSTtcMFKKlTVOMOM04YUQlWWVZLIwzlGdc64Zc9QImct8ZUwJRJbSWcGEzQVjM4THXRNDStE6tYm-0fFXEVC7aJXULlqN0YO_Gv2mXzW2Ouh95QBu9kAno2sXdWt8OriSFlzKYnB3o-u-vW2s-gl9bIfSf_9ej9zpoPQ6DpPLTwqEASGUQV6wP4SsdQM</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Kapingu, M.C</creator><creator>Mbwambo, Z.H</creator><creator>Moshi, M.J</creator><creator>Magadula, J.J</creator><creator>Cos, P</creator><creator>Berghe, D. vanden</creator><creator>Maes, L</creator><creator>Theunis, M</creator><creator>Apers, S</creator><creator>Pieters, L</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20061101</creationdate><title>novel isoflavonoid from Millettia puguensis</title><author>Kapingu, M.C ; Mbwambo, Z.H ; Moshi, M.J ; Magadula, J.J ; Cos, P ; Berghe, D. vanden ; Maes, L ; Theunis, M ; Apers, S ; Pieters, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-73185becf53cfa14755de3d9397cff2a644a33f2c59696bcc801989fe535e6533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>antiprotozoal agents</topic><topic>Antiprotozoal Agents - administration & dosage</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>chemotaxonomy</topic><topic>cytotoxicity</topic><topic>Fabaceae</topic><topic>General pharmacology</topic><topic>human health</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>isoflavones</topic><topic>Isoflavones - administration & dosage</topic><topic>Isoflavones - pharmacology</topic><topic>Isoflavones - therapeutic use</topic><topic>isoflavonoids</topic><topic>Leishmania infantum</topic><topic>Leishmania infantum - drug effects</topic><topic>Leishmaniasis - drug therapy</topic><topic>Letter</topic><topic>maackiain</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Millettia</topic><topic>Millettia puguensis</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>spectral analysis</topic><topic>Trypanosoma - drug effects</topic><topic>Trypanosoma brucei brucei</topic><topic>Trypanosomiasis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapingu, M.C</creatorcontrib><creatorcontrib>Mbwambo, Z.H</creatorcontrib><creatorcontrib>Moshi, M.J</creatorcontrib><creatorcontrib>Magadula, J.J</creatorcontrib><creatorcontrib>Cos, P</creatorcontrib><creatorcontrib>Berghe, D. vanden</creatorcontrib><creatorcontrib>Maes, L</creatorcontrib><creatorcontrib>Theunis, M</creatorcontrib><creatorcontrib>Apers, S</creatorcontrib><creatorcontrib>Pieters, L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapingu, M.C</au><au>Mbwambo, Z.H</au><au>Moshi, M.J</au><au>Magadula, J.J</au><au>Cos, P</au><au>Berghe, D. vanden</au><au>Maes, L</au><au>Theunis, M</au><au>Apers, S</au><au>Pieters, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>novel isoflavonoid from Millettia puguensis</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>72</volume><issue>14</issue><spage>1341</spage><epage>1343</epage><pages>1341-1343</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
From the roots of MILLETTIA PUGUENSIS (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by
1
H-,
13
C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC
50
= 32 μM against LEISHMANIA INFANTUM), and a moderate cytotoxicity for compound 2 (IC
50
= 43 μM on MRC-5 cells).</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>17054049</pmid><doi>10.1055/s-2006-951689</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Planta medica, 2006-11, Vol.72 (14), p.1341-1343 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals antiprotozoal agents Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Biological and medical sciences chemical structure chemotaxonomy cytotoxicity Fabaceae General pharmacology human health Humans Inhibitory Concentration 50 isoflavones Isoflavones - administration & dosage Isoflavones - pharmacology Isoflavones - therapeutic use isoflavonoids Leishmania infantum Leishmania infantum - drug effects Leishmaniasis - drug therapy Letter maackiain Malaria, Falciparum - drug therapy Medical sciences medicinal plants Millettia Millettia puguensis Parasitic Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Plasmodium falciparum Plasmodium falciparum - drug effects spectral analysis Trypanosoma - drug effects Trypanosoma brucei brucei Trypanosomiasis - drug therapy |
| title | novel isoflavonoid from Millettia puguensis |
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