A Stereoselective Oxy-Michael Route to Protected β-Aryl-β-Hydroxy-α-Amino Acids

A Stereoselective Oxy-Michael Route to Protected β-Aryl-β-Hydroxy-α-Amino Acids

Abstract The stereoselective oxy-Michael addition of the ‘naked’ anion of (S)-6-methyl tetrahydropyran-2-ol to α-nitro-α,β-unsaturated esters followed by reduction and in situ protection of the corresponding amine provides a new and efficient route to protected β-aryl-β-hydroxy-α-amino acids....

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Veröffentlicht in:Synlett 2006-10, Vol.2006 (16), p.2673-2675
Hauptverfasser: Hernandez-Juan, Felix A., Richardson, Robert D., Dixon, Darren J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The stereoselective oxy-Michael addition of the ‘naked’ anion of (S)-6-methyl tetrahydropyran-2-ol to α-nitro-α,β-unsaturated esters followed by reduction and in situ protection of the corresponding amine provides a new and efficient route to protected β-aryl-β-hydroxy-α-amino acids.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-950434