First Example of Lewis Acid Catalyzed 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Formation

ABSTRACT A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) trif­late shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter reaction times, higher conversion, and...

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Veröffentlicht in:Synthesis (Stuttgart) 2006-12, Vol.2006 (24), p.4200-4204
Hauptverfasser: Gregg, Brian T., Earley, William G., Golden, Kathryn C., Quinn, John F., Razzano, Dana A., Rennells, W. Martin
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) trif­late shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter reaction times, higher conversion, and better purity profiles as compared to the traditional uncatalyzed reactions.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-950342