One-Step Polyfunctionalization of (Methylthio)thiophenes

One-Step Polyfunctionalization of (Methylthio)thiophenes

ABSTRACT The one-step polyfunctionalization of 2- and 3-(methylthio)thiophenes was investigated. Direct polymetalation with superbases followed by quenching with an appropriate electrophile led to 2,αS-disubstituted derivatives starting from 2-(methyl­thio)thiophene, and 2,5,αS-trisubstituted deriva...

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Veröffentlicht in:Synthesis (Stuttgart) 2006-11, Vol.2006 (22), p.3855-3858
Hauptverfasser: Fattuoni, Claudia, Usai, Michele, Cabiddu, Maria G., Cadoni, Enzo, De Montis, Stefania, Cabiddu, Salvatore
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT The one-step polyfunctionalization of 2- and 3-(methylthio)thiophenes was investigated. Direct polymetalation with superbases followed by quenching with an appropriate electrophile led to 2,αS-disubstituted derivatives starting from 2-(methyl­thio)thiophene, and 2,5,αS-trisubstituted derivatives starting from 3-(methylthio)thiophene.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-950303