Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation

Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation

ABSTRACT The synthesis of regioisomeric spiroisoxazolines was achieved through an intramolecular cyclization/methylation reaction of a functionalized 5,5-disubstituted isoxazoline in one reaction vessel. The 5,5-isoxazoline was constructed through a 1,3-dipolar cycloaddition reaction of an aromatic...

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Veröffentlicht in:Synthesis (Stuttgart) 2006-11, Vol.2006 (22), p.3815-3818
Hauptverfasser: Xu, Jianping, Wang, Jun, Ellis, Erick D., Hamme, Ashton T.
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT The synthesis of regioisomeric spiroisoxazolines was achieved through an intramolecular cyclization/methylation reaction of a functionalized 5,5-disubstituted isoxazoline in one reaction vessel. The 5,5-isoxazoline was constructed through a 1,3-dipolar cycloaddition reaction of an aromatic nitrile oxide and a geminal disubstituted alkene.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-950302