A Unified Strategy for the Regiospecific Assembly of Homoallyl-Substituted Butenolides and γ-Hydroxybutenolides: First Synthesis of Luffariellolide

Abstract The first synthesis of the antiinflammatory marine ­natural product luffariellolide has been achieved by a convergent pathway involving sp 3 -sp 3 cross-coupling and silyloxyfuran oxyfunctionalisation as key steps. An illustration of the inherent ­flexibility of this strategy is provided by a simple synthesis of α,β-acariolide and its γ-hydroxylated derivative from a common silyl­oxyfuran precursor.