Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest

Abstract Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of SCHIZOLAENA HYSTRIX afforded the two new long-chain compounds, 3S-acetoxyeicosanoic acid ethyl ester (1) and 3S-acetoxydoeicosanoic acid (2), and the known long-chain compound 3S-acetoxyeicosanoic acid...

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Veröffentlicht in:	Planta medica 2006-10, Vol.72 (13), p.1235-1238
Hauptverfasser:	Murphy, B.T, Cao, S, Miller, J.S, Ratovoson, F, Andriantsiferana, R, Rasamison, V.E, Kingston, D.G.I
Format:	Artikel
Sprache:	eng
Schlagworte:	acetoxyeicosanoic acid anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - toxicity Biological and medical sciences Cell Line, Tumor Chemical Fractionation chemical structure cultured cells cytotoxicity Eicosanoic Acids - chemistry Eicosanoic Acids - isolation & purification Eicosanoic Acids - toxicity esters Flavanones - chemistry Flavanones - isolation & purification Flavanones - toxicity flavonoids General pharmacology Humans Lauric Acids - chemistry Lauric Acids - isolation & purification Lauric Acids - toxicity Letter long chain fatty acids Madagascar Magnoliopsida - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant products Sarcolaenaceae Schizolaena hystrix schizolaenone spectral analysis Tropical Climate
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Zusammenfassung:	Abstract Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of SCHIZOLAENA HYSTRIX afforded the two new long-chain compounds, 3S-acetoxyeicosanoic acid ethyl ester (1) and 3S-acetoxydoeicosanoic acid (2), and the known long-chain compound 3S-acetoxyeicosanoic acid (3). In addition, the long-chain alcohol 1-hydroxydodecan-2-one (7), as well as the new flavonoid schizolaenone C (4) and the two known flavonoids diplacol (5) and 3′-prenylnaringenin (6) were isolated from a methanol extract of the same plant. Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-947192