Enantioselective Synthesis of (+)-(S,S)-Reboxetine

Enantioselective Synthesis of (+)-(S,S)-Reboxetine

Abstract An efficient enantioselective synthesis leading directly to (+)-(S,S)-reboxetine has been described from commercially available TRANS-cinnammyl bromide using Sharpless asymmetric dihydroxylation as the key step.

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Veröffentlicht in:Synlett 2006-07, Vol.2006 (11), p.1771-1773
Hauptverfasser: Siddiqui, Shafi A., Narkhede, Umesh C., Lahoti, Rajgopal J., Srinivasan, Kumar V.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract An efficient enantioselective synthesis leading directly to (+)-(S,S)-reboxetine has been described from commercially available TRANS-cinnammyl bromide using Sharpless asymmetric dihydroxylation as the key step.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-944210