Studies on the Base-Catalysed Addition of Amines to Alkynes and Allenes: A Novel Cascade Sequence for the Construction of Spirocyclic Aminals

Abstract Indoles can be prepared by the intramolecular addition of resin bound amides to allenyl sulfoxides. Amino alkynols have been converted into spirocyclic aminals in one synthetic operation re­presenting an enormous increase in molecular complexity.

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Veröffentlicht in:Synlett 2006-03, Vol.2006 (4), p.0654-0656
Hauptverfasser: Höenke, Nicole, Payne, Lloyd J., Parsons, Philip J., Hitchcock, Peter B.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Indoles can be prepared by the intramolecular addition of resin bound amides to allenyl sulfoxides. Amino alkynols have been converted into spirocyclic aminals in one synthetic operation re­presenting an enormous increase in molecular complexity.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-932486