new cytotoxic amide from the stem wood of Hibiscus tiliaceus

Abstract A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N-TRANS-feruloyltyramine, N-CIS-feruloyltyramine, a mixture of β-sitosterol and stigmasterol, a...

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Veröffentlicht in:	Planta medica 2006-08, Vol.72 (10), p.935-938
Hauptverfasser:	Chen, J.J, Huang, S.Y, Duh, C.Y, Chen, I.S, Wang, T.C, Fang, H.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Acrylamides - isolation & purification Acrylamides - toxicity amides Amides - chemistry Amides - isolation & purification Amides - toxicity Animals anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - toxicity Biological and medical sciences Cell Line, Tumor chemical structure coumarins Coumarins - chemistry Coumarins - isolation & purification Coumarins - toxicity cultured cells cytotoxicity Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - toxicity General pharmacology Guaiacol - analogs & derivatives Guaiacol - chemistry Guaiacol - isolation & purification Guaiacol - toxicity Hibiscus Hibiscus - chemistry hibiscusamide hibiscusin Humans Hydroxybenzoates - chemistry Hydroxybenzoates - isolation & purification Hydroxybenzoates - toxicity Letter Malvaceae Mass Spectrometry Medical sciences Mice Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - toxicity Plant Stems - chemistry spectral analysis stereochemistry Steroids - chemistry Steroids - isolation & purification Steroids - toxicity Talipariti tiliaceum
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Zusammenfassung:	Abstract A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N-TRANS-feruloyltyramine, N-CIS-feruloyltyramine, a mixture of β-sitosterol and stigmasterol, a mixture of β-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of HIBISCUS TILIACEUS. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC 50 values < 4 μg/mL) against P-388 and/or HT-29 cell lines IN VITRO.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-931604