Synthesis of 4,4′-Disubstituted Azepines via Ring-Closing Metathesis Reaction and Asymmetric Arylation of Lactones

ABSTRACT The syntheses of the title compounds were accomplished via an original sequence of reactions including the ring-closing metathesis­ of ω-dienes by using the second-generation Grubbs’ catalyst. The chiral diene precursors are available in racemic or optically enriched form from the corresponding α,α′-disubstituted lactones derivatives