Deprotection of o-Nitrobenzensulfonyl (Nosyl) Derivatives of Amines ­Mediated by a Solid-Supported Thiol

Deprotection of o-Nitrobenzensulfonyl (Nosyl) Derivatives of Amines ­Mediated by a Solid-Supported Thiol

Abstract A new protocol based on a solid-supported thiol was ­developed for high yielding deprotection of O-nitrobenzensulfonyl amides derived from primary and secondary amines. The reaction can be carried out at room temperature for 24 hours or accelerated by microwave irradiation, going to complet...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Synlett 2005-12, Vol.2005 (19), p.2996-2998
Hauptverfasser: Cardullo, Francesca, Donati, Daniele, Merlo, Giancarlo, Paio, Alfredo, Salaris, Margherita, Taddei, Maurizio
Format: Artikel
Sprache:eng
Schlagworte:
letter
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract A new protocol based on a solid-supported thiol was ­developed for high yielding deprotection of O-nitrobenzensulfonyl amides derived from primary and secondary amines. The reaction can be carried out at room temperature for 24 hours or accelerated by microwave irradiation, going to completion in six minutes.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-921892