Cytotoxic flavonoids and new chromenes from Ficus formosana f. formosana

Abstract Two new chromenes, ficuformodiol A (1) and ficuformodiol B (2), and nine known compounds including one chromene, spatheliachromen (3), six flavonoids, obovatin (4), carpachromene (5), apigenin (6), norartocarpetin (7), steppogenin (8), 6-prenylpinocembrin (9), one benzopyran, chromenylacryl...

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Veröffentlicht in:	Planta medica 2005-12, Vol.71 (12), p.1165-1167
Hauptverfasser:	Sheu, Y.W, Chiang, L.C, Chen, Y.C, Tsai, I.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Benzopyrans - chemistry Benzopyrans - pharmacology Benzopyrans - toxicity Biological and medical sciences Cell Line, Tumor chemical structure chromenes cultured cells cytotoxicity ficuformodiol Ficus Ficus - chemistry Ficus formosana f. formosana flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flavonoids - toxicity General pharmacology Humans Letter Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Stems - chemistry spectral analysis
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Zusammenfassung:	Abstract Two new chromenes, ficuformodiol A (1) and ficuformodiol B (2), and nine known compounds including one chromene, spatheliachromen (3), six flavonoids, obovatin (4), carpachromene (5), apigenin (6), norartocarpetin (7), steppogenin (8), 6-prenylpinocembrin (9), one benzopyran, chromenylacrylic acid (10), and one isocoumarin, (R)-(-)-mellein (11), were obtained from the cytotoxic chloroform-soluble fraction of the stems of FICUS FORMOSANA f. FORMOSANA (Moraceae). Their structures were determined by means of spectroscopic analyses. Compounds 5, 6 and 7 exhibited significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines IN VITRO.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2005-873163