Three-Component Procedure for the Synthesis of 5-Aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic Acids

Three-Component Procedure for the Synthesis of 5-Aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic Acids

ABSTRACT Three-component condensation of pyruvic acid with aromatic aldehydes and some aminoazoles was developed as a procedure for the synthesis 5-aryl-5,8-dihydroazolo[1,5-A]pyrimidine-7-carboxylic acids. An influence of solvent type on the composition of the reaction products was found. The struc...

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Veröffentlicht in:Synthesis (Stuttgart) 2005-10, Vol.2005 (15), p.2597-2601
Hauptverfasser: Chebanov, Valentin A., Sakhno, Yana I., Desenko, Sergey M., Shishkina, Svetlana V., Musatov, Vladimir I., Shishkin, Oleg V., Knyazeva, Irina V.
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT Three-component condensation of pyruvic acid with aromatic aldehydes and some aminoazoles was developed as a procedure for the synthesis 5-aryl-5,8-dihydroazolo[1,5-A]pyrimidine-7-carboxylic acids. An influence of solvent type on the composition of the reaction products was found. The structures of the compounds obtained were proved by 1 H and 13 C NMR spectroscopy, NOE experiments, and X-ray analysis.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-872073