Stereofacial Control in Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel S-Proline-Derived Titanium Complexes
Abstract Asymmetric cyanosilylation of aryl aldehydes has been achieved utilizing catalytic amounts of novel chiral ligands. Chiral ligands of amino alcohols and aminophosphine gave S-configured cyanosilylated products with up to 84% ee. In contrast, C 2 -symmetric ligands resulted in R-configured p...
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| Veröffentlicht in: | Synlett 2005-08, Vol.2005 (13), p.1995-1998 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
Asymmetric cyanosilylation of aryl aldehydes has been achieved utilizing catalytic amounts of novel chiral ligands. Chiral ligands of amino alcohols and aminophosphine gave S-configured cyanosilylated products with up to 84% ee. In contrast, C
2
-symmetric ligands resulted in R-configured products with up to 95% ee. |
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| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2005-871971 |