Synthesis of Diarylamines in the Thiophene Series by Buchwald-Hartwig Coupling

Synthesis of Diarylamines in the Thiophene Series by Buchwald-Hartwig Coupling

ABSTRACT We describe here the palladium-catalyzed amination of polysubstituted bromothiophenes under mild conditions (using Cs 2 CO 3 as base). Anilines bearing electron-donating groups gave good results whereas anilines with electron-withdrawing substituents required greater catalyst loadings and g...

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Veröffentlicht in:Synthesis (Stuttgart) 2005-09, Vol.2005 (14), p.2373-2378
Hauptverfasser: Begouin, Agathe, Hesse, Stéphanie, Queiroz, Maria-João R., Kirsch, Gilbert
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT We describe here the palladium-catalyzed amination of polysubstituted bromothiophenes under mild conditions (using Cs 2 CO 3 as base). Anilines bearing electron-donating groups gave good results whereas anilines with electron-withdrawing substituents required greater catalyst loadings and gave lower yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-870014