Novel Approach to Isoindolo[2,1-a]quinolines: Synthesis of 1- and 3-Halo-Substituted 11-Oxo-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinoline-10-carboxylic Acids

Novel Approach to Isoindolo[2,1-a]quinolines: Synthesis of 1- and 3-Halo-Substituted 11-Oxo-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinoline-10-carboxylic Acids

ABSTRACT A series of 1- and 3-halo-substituted isoindolo[2,1-A]quinolines were obtained by means of electrophilic cyclization of methallyl- and allyl-substituted isoindolo-7-carboxylic acids. The influence of halogen atoms on the stereochemistry of the formation of key intermediates, 3a,6-epoxyisoin...

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Veröffentlicht in:Synthesis (Stuttgart) 2005-07, Vol.2005 (11), p.1859-1875
Hauptverfasser: Boltukhina, Ekaterina V., Zubkov, Fedor I., Nikitina, Eugenia V., Varlamov, Alexey V.
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT A series of 1- and 3-halo-substituted isoindolo[2,1-A]quinolines were obtained by means of electrophilic cyclization of methallyl- and allyl-substituted isoindolo-7-carboxylic acids. The influence of halogen atoms on the stereochemistry of the formation of key intermediates, 3a,6-epoxyisoindoles, was studied.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-869948