Proline-Catalyzed Asymmetric Direct Aldol Reaction Assisted by d-Camphorsulfonic Acid in Aqueous Media

Proline-Catalyzed Asymmetric Direct Aldol Reaction Assisted by d-Camphorsulfonic Acid in Aqueous Media

ABSTRACT Asymmetric aldol reactions of aromatic aldehydes with various ketones catalyzed by L-proline with D-camphorsulfonic acid as co-catalyst have been developed in aqueous media. High reactivity and modest to excellent enantioselectivity has been achieved.

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Veröffentlicht in:Synlett 2005-06, Vol.2005 (10), p.1627-1629
Hauptverfasser: Wu, Yin-Su, Chen, Yi, Deng, Dong-Sheng, Cai, Jiwen
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT Asymmetric aldol reactions of aromatic aldehydes with various ketones catalyzed by L-proline with D-camphorsulfonic acid as co-catalyst have been developed in aqueous media. High reactivity and modest to excellent enantioselectivity has been achieved.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-869864