Synthesis and Application of 4′-C-Alkylated Uridines as Probes for Uracil-DNA Glycosylase

Synthesis and Application of 4′-C-Alkylated Uridines as Probes for Uracil-DNA Glycosylase

Abstract The development of new synthetic probes to study the mechanism of Uracil-DNA glycosylase is described. 4′-C-Alkylated 2′-deoxyuridines were synthesized and incorporated site-specifically into oligonucleotides. These compounds were subsequently employed in functional studies of the enzyme an...

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Veröffentlicht in:Synthesis (Stuttgart) 2005-06, Vol.2005 (9), p.1467-1472
Hauptverfasser: Rangam, Gopinath, Rudinger, Nicolas Z., Müller, H. Martin, Marx, Andreas
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The development of new synthetic probes to study the mechanism of Uracil-DNA glycosylase is described. 4′-C-Alkylated 2′-deoxyuridines were synthesized and incorporated site-specifically into oligonucleotides. These compounds were subsequently employed in functional studies of the enzyme and proved to be functional competent.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-865328