A Flexible, Efficient Synthesis of (±)-Carbocyclic Phosphonic Acid Nucleoside Derivatives

A Flexible, Efficient Synthesis of (±)-Carbocyclic Phosphonic Acid Nucleoside Derivatives

Abstract An efficient and flexible synthesis of cyclopentane and hydroxylated cyclopentane phosphonic acid analogues is described. The key step involves the opening of an epoxide with either a nu­cleoside base or a selenyl anion to access the target molecules.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Synlett 2005-03, Vol.2005 (5), p.0765-0768
Hauptverfasser: Wainwright, Phillip, Maddaford, Adrian, Bissell, Richard, Fisher, Ray, Leese, David, Lund, Andrew, Runcie, Karen, Dragovich, Peter S., Gonzalez, Javier, Kung, Pei-Pei, Middleton, Donald S., Pryde, David C., Stephenson, Peter T., Sutton, Scott C.
Format: Artikel
Sprache:eng
Schlagworte:
letter
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract An efficient and flexible synthesis of cyclopentane and hydroxylated cyclopentane phosphonic acid analogues is described. The key step involves the opening of an epoxide with either a nu­cleoside base or a selenyl anion to access the target molecules.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-863745