Sequential Sonogashira and Suzuki Cross-Coupling Reactions in the Indole and Indazole Series

Sequential Sonogashira and Suzuki Cross-Coupling Reactions in the Indole and Indazole Series

ABSTRACT 3-Iodoindoles, 5-bromo-3-iodoindoles and 5-bromo-3-iodoindazoles have been studied with respect to their reactivity and selectivity in palladium catalyzed Sonogashira and Suzuki cross-coupling reactions. As a result, sequential Sonogashira-Sonoga­shira, Sonogashira-Suzuki, and Suzuki-Sonoga...

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Veröffentlicht in:Synthesis (Stuttgart) 2005-04, Vol.2005 (5), p.771-780
Hauptverfasser: Witulski, Bernhard, Azcon, Javier Ramon, Alayrac, Carole, Arnautu, Anca, Collot, Valérie, Rault, Sylvain
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT 3-Iodoindoles, 5-bromo-3-iodoindoles and 5-bromo-3-iodoindazoles have been studied with respect to their reactivity and selectivity in palladium catalyzed Sonogashira and Suzuki cross-coupling reactions. As a result, sequential Sonogashira-Sonoga­shira, Sonogashira-Suzuki, and Suzuki-Sonogashira reactions with 5-bromo-3-iodoindoles or indazoles were used to obtain a large range of new functionalized indoles and indazoles, which are potential 5-HT receptor ligands.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-861825