Nicotinoyl Azide (NCA)-Mediated Mitsunobu Reaction: An Expedient One-Pot Transformation of Alcohols into Azides

Abstract A practical and simple method that allows preparation of azides from alcohols is described. The process involves oxyphosphonium-type activation and it is based upon the use of nicotinoyl azide (NCA), a cheap and easily accessible azide ion source.

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Veröffentlicht in:Synthesis (Stuttgart) 2004-12, Vol.2004 (17), p.2886-2892
Hauptverfasser: Papeo, Gianluca, Posteri, Helena, Vianello, Paola, Varasi, Mario
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A practical and simple method that allows preparation of azides from alcohols is described. The process involves oxyphosphonium-type activation and it is based upon the use of nicotinoyl azide (NCA), a cheap and easily accessible azide ion source.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2004-831254