A Mild and Efficient Oxidative Deprotection of THP Ethers with NBS in the Presence of β-Cyclodextrin in Water

A Mild and Efficient Oxidative Deprotection of THP Ethers with NBS in the Presence of β-Cyclodextrin in Water

Abstract An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N-bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. A series of tetrahydropyranyl ethers were oxidatively deprotected at room temperature in impressiv...

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Veröffentlicht in:Synthesis (Stuttgart) 2004-08, Vol.2004 (11), p.1741-1743
Hauptverfasser: Narender, M., Reddy, M. Somi, Rao, K. Rama
Format: Artikel
Sprache:eng
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short paper
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Zusammenfassung:Abstract An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N-bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. A series of tetrahydropyranyl ethers were oxidatively deprotected at room temperature in impressive yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2004-829148