A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam

A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam

ABSTRACT A facile five-step route to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, with 64% overall yield has been demonstrated starting from citraconimide (5) via regioselective NaBH 4 reduction, catalytic hydrogenation, resin-catalyzed dehydration, N-BOC...

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Veröffentlicht in:Synthesis (Stuttgart) 2004-07, Vol.2004 (10), p.1560-1562
Hauptverfasser: Mangaleswaran, Sivaprakasam, Argade, Narshinha P.
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creator Mangaleswaran, Sivaprakasam
Argade, Narshinha P.
description ABSTRACT A facile five-step route to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, with 64% overall yield has been demonstrated starting from citraconimide (5) via regioselective NaBH 4 reduction, catalytic hydrogenation, resin-catalyzed dehydration, N-BOC protection, and stereoselective condensation pathway.
doi_str_mv 10.1055/s-2004-822407
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title A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam
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