A Facile Synthesis of CD45 Protein Tyrosine Phosphatase Inhibitor Marine Natural Product Pulchellalactam
ABSTRACT A facile five-step route to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, with 64% overall yield has been demonstrated starting from citraconimide (5) via regioselective NaBH 4 reduction, catalytic hydrogenation, resin-catalyzed dehydration, N-BOC...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2004-07, Vol.2004 (10), p.1560-1562 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | ABSTRACT
A facile five-step route to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, with 64% overall yield has been demonstrated starting from citraconimide (5) via regioselective NaBH
4
reduction, catalytic hydrogenation, resin-catalyzed dehydration, N-BOC protection, and stereoselective condensation pathway. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2004-822407 |