A Short Synthetic Approach to Chiral Serine Azido Derivatives

A Short Synthetic Approach to Chiral Serine Azido Derivatives

Abstract We report a new synthetic methodology for the synthesis of chiral serine azido derivatives through a conversion of N-protected (Boc, Cbz and Fmoc) serine amino acid into its corresponding Weinreb amide. Thus, acidity of the α-proton of the serine is reduced and it allows nucleophilic additi...

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Veröffentlicht in:Synlett 2004-03, Vol.2004 (4), p.714-716
Hauptverfasser: Panda, Gautam, Rao, N. Venugopal
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract We report a new synthetic methodology for the synthesis of chiral serine azido derivatives through a conversion of N-protected (Boc, Cbz and Fmoc) serine amino acid into its corresponding Weinreb amide. Thus, acidity of the α-proton of the serine is reduced and it allows nucleophilic addition reaction onto Weinreb amide to furnish chiral serine azido derivatives.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-817770