A Facile Route to Pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazoles, Novel Heterocyclic Derivatives
ABSTRACT The title system derivatives were prepared in two steps. Thus the condensation of 2-benzimidazoleacetonitrile with ethyl 4-chloro-3-oxobutanoate led to the 3-chloromethyl-1,5-dihydro-1-oxopyrido[1,2-A]benzimidazole-4-carbonitrile. Further amination of the obtained chloronitrile with primar...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2004-02, Vol.2004 (3), p.373-376 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | ABSTRACT
The title system derivatives were prepared in two steps. Thus the condensation of 2-benzimidazoleacetonitrile with ethyl 4-chloro-3-oxobutanoate led to the 3-chloromethyl-1,5-dihydro-1-oxopyrido[1,2-A]benzimidazole-4-carbonitrile. Further amination of the obtained chloronitrile with primary amines yielded 1-amino-2,3-dihydro-2-R-5H-pyrrolo[3′,4′:3,4]pyrido[1,2-A]benzimidazol-5-ones. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2004-815950 |