A One-Pot Conversion of α-Aminoalkylphosphonous Acids into Monomethyl α-Aminoalkylphosphonates
ABSTRACT An excellent method for a one-pot conversion of N-protected α-aminoalkylphosphonous acids into the corresponding monomethyl phosphonates, using thionyl chloride in methanol, has been devised. N-Protected monomethyl α-aminoalkylphosphonates are valuable intermediates in the preparation of ph...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2004-02, Vol.2004 (3), p.359-362 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | ABSTRACT
An excellent method for a one-pot conversion of N-protected α-aminoalkylphosphonous acids into the corresponding monomethyl phosphonates, using thionyl chloride in methanol, has been devised. N-Protected monomethyl α-aminoalkylphosphonates are valuable intermediates in the preparation of phosphapeptides. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2004-815922 |