Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Abstract A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of CREMASTRA APPENDICULATA (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced IN VITRO angiogen...

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Veröffentlicht in:	Planta medica 2004-02, Vol.70 (2), p.171-173
Hauptverfasser:	Shim, J.S, Kim, J.H, Lee, J, Kim, S.N, Kwon, H.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals antiangiogenic activity Biological and medical sciences cell proliferation chemical structure Chick Embryo chorioallantoic membrane Chorion - blood supply Chorion - drug effects Cremastra appendiculata endothelial cells Fibroblast Growth Factor 2 - drug effects General pharmacology homoisoflavanone humans isoflavones Isoflavones - administration & dosage Isoflavones - pharmacology Isoflavones - therapeutic use Letter Medical sciences medicinal plants medicinal properties Neovascularization, Physiologic - drug effects Orchidaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments physiologic angiogenesis phytochemicals Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use spectral analysis umbilical veins
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Zusammenfassung:	Abstract A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of CREMASTRA APPENDICULATA (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced IN VITRO angiogenesis and IN VIVO angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2004-815496