Semisynthetic Di- and Tri-Functionalized Non-Immunosuppressive Cyclosporin A Derivatives as Potential Anti-HIV 1 Drugs

Semisynthetic Di- and Tri-Functionalized Non-Immunosuppressive Cyclosporin A Derivatives as Potential Anti-HIV 1 Drugs

Abstract A regio- and stereoselective synthesis of original semisynthetic di- and tri-functionalized non-immunosuppressive ­cyclosporins by way of a Barton ester decarboxylation and a C-thioalkylation starting from cyclosporin A (CsA) and [4′-hydroxy-­MeLeu] 4 -CsA is described.

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Veröffentlicht in:Synlett 2004-02, Vol.2004 (2), p.0316-0320
Hauptverfasser: Carry, Jean-Christophe, Evers, Michel, Barrière, Jean-Claude, Bashiardes, Georges, Bensoussan, Claude, Gueguen, Jean-Christophe, Dereu, Norbert, Filoche, Bruno, Sablé, Serge, Vuilhorgne, Marc, Mignani, Serge
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Sprache:eng
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Zusammenfassung:Abstract A regio- and stereoselective synthesis of original semisynthetic di- and tri-functionalized non-immunosuppressive ­cyclosporins by way of a Barton ester decarboxylation and a C-thioalkylation starting from cyclosporin A (CsA) and [4′-hydroxy-­MeLeu] 4 -CsA is described.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-815405