Cyclisations Involving Attack of Carbo- and Heteronucleophiles on Carbon-Carbon π-Bonds Activated by Organopalladium Complexes

Abstract In the late 1980’s, a new process based on an intramolecular palladium-mediated cyclisation coupled with a carbon-carbon bond forming reaction appeared in the literature. Since the first report, many novel ring systems have been synthesized using this methodology. The aim of this present review article is to summarise a number of synthetic applications of this new process developed over the last fifteen years. 1 Introduction 2 Carbocycles 2.1 Cyclisation Unactivated Olefins 2.2 Cyclisation of Unactivated Alkynes 3 Heterocycles 3.1 Oxygen Heterocycles 3.2 Nitrogen Heterocycles 4 Conclusion