Molecular Sieve (MS 4A) Promoted Cyclocondensation of Hindered, Aromatic Nitrile Oxides and Cyclic Diketones under Mild Conditions

Molecular Sieve (MS 4A) Promoted Cyclocondensation of Hindered, Aromatic Nitrile Oxides and Cyclic Diketones under Mild Conditions

Abstract Molecular sieves (MS 4A) serve as efficient promoters for the cyclocondensation of stable, hindered nitrile oxides and a variety of cyclic diketones to afford fused isoxazoles in good yield. The operational simplicity and remarkably mild reaction conditions compliment our amine-promoted cyc...

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Veröffentlicht in:Synlett 2003, Vol.2003 (11), p.1746-1748
Hauptverfasser: Matsuura, Tomoo, Bode, Jeffrey W., Hachisu, Yoshifumi, Suzuki, Keisuke
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Sprache:eng
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Zusammenfassung:Abstract Molecular sieves (MS 4A) serve as efficient promoters for the cyclocondensation of stable, hindered nitrile oxides and a variety of cyclic diketones to afford fused isoxazoles in good yield. The operational simplicity and remarkably mild reaction conditions compliment our amine-promoted cyclocondensation conditions and demonstrate broad substrate scope.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-41436