Effects of Fucoidan on Chronic Renal Failure in Rats

Abstract The effects of fucoidan on chronic renal failure (CRF) were investigated IN VIVO in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum...

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Veröffentlicht in:	Planta medica 2003-06, Vol.69 (6), p.537-541
Hauptverfasser:	Zhang, Quanbin, Li, Zhien, Xu, Zuhong, Niu, Xizhen, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Blood Flow Velocity Blood Urea Nitrogen Disease Models, Animal Dogs Dose-Response Relationship, Drug General pharmacology Kidney - blood supply Kidney - drug effects Kidney - injuries Kidney Failure, Chronic - prevention & control Laminaria Male Medical sciences Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Polysaccharides - administration & dosage Polysaccharides - pharmacology Polysaccharides - therapeutic use Rats Rats, Wistar Renal Artery - physiology
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Zusammenfassung:	Abstract The effects of fucoidan on chronic renal failure (CRF) were investigated IN VIVO in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2003-40634